Journal: NeuroImage

Article Title: Ex Vivo Fetal Brain MRI: Recent Advances, Challenges, and Future Directions

doi: 10.1016/j.neuroimage.2019.03.034

Figure Lengend Snippet: Note that regions with FA values lower than 0.15–0.2 are observed in the majority (40 GW) and peripheral regions (3 years old) of the arcuate fasciculus that cannot be detected with popular DTI analysis methods with an FA threshold (Modified from Wilkinson et al., 2017, with permission). In addition to other technical issues including the quality of MRI scan acquisition and analysis, thresholding parameters based on FA values are important factors when performing tractography.

Article Snippet: The structural MRI scan is made available by the Allen Institute for Brain Science ( Miller et al. , 2014 ), and is available at: http://download.alleninstitute.org/brainspan/MRI_DTI_data_for_prenatal_specimens/ .

Techniques: Modification

Journal: NeuroImage

Article Title: Ex Vivo Fetal Brain MRI: Recent Advances, Challenges, and Future Directions

doi: 10.1016/j.neuroimage.2019.03.034

Figure Lengend Snippet: The GE wanes between GW 20 and 30. Coronal planes from a structural T1w MRI scans of a human at GW19 show cell dense regions consisting of the GE and cortical proliferative pool (CPP). Comparing the growth of these two proliferative pools throughout development in humans, macaques, and mice permits identifying evolutionary changes in neurogenesis timing across species. The structural MRI scan is made available by the Allen Institute for Brain Science (Miller et al., 2014), and is available at: http://download.alleninstitute.org/brainspan/MRI_DTI_data_for_prenatal_specimens/. Image credit: Allen Institute.

Article Snippet: The structural MRI scan is made available by the Allen Institute for Brain Science ( Miller et al. , 2014 ), and is available at: http://download.alleninstitute.org/brainspan/MRI_DTI_data_for_prenatal_specimens/ .

Techniques:

Journal: NeuroImage

Article Title: Ex Vivo Fetal Brain MRI: Recent Advances, Challenges, and Future Directions

doi: 10.1016/j.neuroimage.2019.03.034

Figure Lengend Snippet: (A) The timing of developmental transformations (expressed as age in days after conception in macaques and humans) is regressed against equivalent developmental transformations found in mice (Workman et al., 2013; Charvet et al., 2017b, Charvet and Finlay, 2018; Charvet et al., 2018). The timing of developmental transformations is instrumental in identifying corresponding ages across species. Such an approach permits identifying variation in the timing of select developmental processes after controlling for variation in developmental schedules across species. Using this approach, Charvet et al. (2017a) found that the ganglionic eminence (GE) (B) and cortical proliferative pool (C) grow for significantly longer in humans and macaques once overall differences in the duration of developmental schedules are controlled for (see Workman et al., 2013; Charvet et al., 2017a; Charvet and Finlay, 2018; Charvet et al., 2018). (D) Examples of equivalent developmental time points are shown from reconstructed structural MRI scans and micro CT-scans. Micro CT-scans of prenatal mice are from Wong et al., 2012. Structural MR scans of prenatal humans are from the multi-dimensional human embryo project (http://embryo.soad.umich.edu/index.html).

Article Snippet: The structural MRI scan is made available by the Allen Institute for Brain Science ( Miller et al. , 2014 ), and is available at: http://download.alleninstitute.org/brainspan/MRI_DTI_data_for_prenatal_specimens/ .

Techniques: Micro-CT